After Arizona's defense forced a three-and-out, the Cardinals received possession. After finding tight end Trey McBride on a 22-yard gain, Murray kept the ball on a quarterback keeper and went untouched on a 50-yard run to the end zone.

Arizona Cardinals quarterback Kyler Murray broke free for a 50-yard touchdown run on the team's second play of the game

SANTA CLARA, Calif. -- Kyler Murray knew it. Six yards into his 50-yard touchdown run less than two minutes into the first quarter, Arizona Cardinals quarterback knew he was gone. On first-and-10 from the 50, he faked a handoff to running back James Conner and then took off to his right.